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Article

A model of developmental evolution: selection, pleiotropy and compensation.

Trends in ecology & evolution - 1 Jun 2012

Pavlicev Mihaela, Wagner Günter P

Abstract excerpt

Development and physiology translate genetic variation into phenotypic variation and determine the genotype-phenotype map, such as which gene affects which character (pleiotropy). Any genetic change in this mapping reflects a change in development. Here, we discuss evidence for variation in pleiotropy and propose the selection, pleiotropy and compensation model (SPC) for adaptive evolution. It predicts that...

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PMID: 22385978
DOI: 10.1016/j.tree.2012.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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