Article

Considerations in planning a controlled human infection model in at-risk groups in sub-Saharan Africa: the case for pneumococcal challenge in people living with HIV in Malawi and a report of stakeholder consultation

2024-11-07

Abstract excerpt

Controlled human infection models offer a unique opportunity to understand infectious disease pathogenesis and have accelerated vaccine development and evaluations in malaria and typhoid. One major limitation of most CHIMs is that they are typically conducted in healthy young adults who are generally the population least affected by infectious disease, and who exhibit distinct disease profiles to more at-risk popu...

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Literature Corpus work: 548879ef-79a0-53cd-8f52-64db4de4a62c
DOI: 10.12688/wellcomeopenres.23277.1

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