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Article

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection

2 Apr 2015

Abstract excerpt

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spreading mechanism, which is also a characteristic of some important computer worm outbreaks, to HIV-1 progression in vivo remains unknown. Here we present a new...

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PMID: 25837979
DOI: 10.1371/journal.pcbi.1004179

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