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The human leucocyte antigen‐G 14‐basepair polymorphism correlates with graft‐versus‐host disease in unrelated bone marrow transplantation for thalassaemia

25 Sept 2007

Abstract excerpt

The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease...

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PMID: 17897304
DOI: 10.1111/j.1365-2141.2007.06779.x

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