Article
HLA-G 14-bp insertion/deletion polymorphism in kidney transplant patients with metabolic complications.
Transplantation proceedings - 1 May 2009
Piancatelli D, Maccarone D, Liberatore G, Parzanese I, Clemente K, Azzarone R, Pisani F, Famulari A, Papola F
Abstract excerpt
HLA-G, a nonclassical HLA molecule with limited polymorphism has immunomodulating/tolerogenic properties. The most common polymorphism of HLA-G is a deletion/insertion of 14 bp, located at the 3'UTR region of the gene (exon 8). This polymorphism is associated with modifications of mRNA stability that can lead to variations of membrane versus soluble HLA-G expression. HLA-G may be involved in the clinical outcomes...
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