Article
Chemotherapy sensitivity recovery of prostate cancer cells by functional inhibition and knock down of multidrug resistance proteins.
The Prostate - 1 Dec 2011
Sánchez Catherine, Mercado Alejandro, Contreras Héctor R, Mendoza Patricia, Cabezas Juan, Acevedo Cristian, Huidobro Christian, Castellón Enrique A
Abstract excerpt
BACKGROUND: In several cancer types, expression of multidrug resistance (MDR) proteins has been associated with lack of chemotherapy response. In advanced prostate cancer (PCa) the use of chemotherapy is mainly palliative due to its high resistance. Previously, we described that MDR phenotype in PCa could be related with high basal and drug-induced expression of MDR proteins P-Glycoprotein (P-Gp), MRP1, and LRP....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.