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Article

The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines

1 Jan 2019

Abstract excerpt

One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition (EMT) program which has been associated with chemoresistance in tumoral cells. The transcription factor zinc finger E-box-binding homeobox 1 (ZEB1), a key EMT activator, has recently been related to docetaxel resistance, the main chemotherapeutic used in advanced prostate cancer treatment. The...

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PMID: 30880686
DOI: 10.4103/aja.aja_1_19

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