Article
Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells.
Oncology reports - 1 Oct 2005
Nomura Takeo, Yamasaki Mutsushi, Nomura Yoshio, Mimata Hiromitsu
Abstract excerpt
Acquired multi-drug resistance remains a major obstacle in the management of prostate cancer. The objective of this study was to examine whether chemoresistance could be due in part to the expression of the inhibitors of apoptosis proteins (IAPs). We established cisplatin-resistant LNCaP sublines. We examined the effects of cisplatin on cell growth and apoptosis in LNCaP cells and LNCaP sublines by...
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