Article
Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines.
The Journal of urology - 1 Nov 1993
Theyer G, Schirmböck M, Thalhammer T, Sherwood E R, Baumgartner G, Hamilton G
Abstract excerpt
The treatment of advanced metastatic prostate cancer by hormone manipulation or orchiectomy is frequently followed by the appearance of hormone-insensitive and highly chemoresistant tumor cells. In this study we have investigated the contribution of the P-glycoprotein-mediated drug efflux (multidrug-resistance; MDR) to the cellular resistance of prostate carcinoma-derived cell lines to diverse cytotoxic drugs by...
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