Article
Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines.
The Journal of urology - 1 Nov 1993
Theyer G, Schirmböck M, Thalhammer T, Sherwood E R, Baumgartner G, Hamilton G
Abstract excerpt
The treatment of advanced metastatic prostate cancer by hormone manipulation or orchiectomy is frequently followed by the appearance of hormone-insensitive and highly chemoresistant tumor cells. In this study we have investigated the contribution of the P-glycoprotein-mediated drug efflux (multid...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenocarcinoma
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Carrier Proteins
- Cell Division
- Cyclosporine
- Doxorubicin
- Drug Resistance
- Humans
- Male
- Membrane Glycoproteins
- Phenotype
- Prostatic Neoplasms
- Rhodamine 123
- Rhodamines
- Tamoxifen
- Tumor Cells, Cultured