Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survival of docetaxel-resistant prostate cancer cells in vitro depends on phenotype alterations and continuity of drug exposure.

Cellular and molecular life sciences : CMLS - 1 Jul 2002

Makarovskiy A N, Siryaporn E, Hixson D C, Akerley W

Abstract excerpt

We evaluated in vitro the effect of paclitaxel and docetaxel on PC-3 and DU-145 prostate cancer cell lines to understand better the downstream events in drug-induced tumor cell death. Taxane treatments of DU-145 cells induced rapid cell death by apoptosis, but in PC-3 cells, treatments achieved growth arrest, followed by extensive karyokinesis resulting in multinucleation, giant-cell formation and delayed cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to bcl-X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Docetaxel

Share to Giant Cells

Share to Paclitaxel

Share to Proto-Oncogene Proteins c-bcl-2

Share to Taxoids

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 12222966
DOI: 10.1007/s00018-002-8498-3
PMCID: PMC11337514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survival of docetaxel-resistant prostate cancer cells in vitro depends on phenotype alterations and continuity of drug exposure.PMID 12222966Read ↗

Gene expression profiling of the androgen independent prostate cancer cells demonstrates complex mechanisms mediating resistance to docetaxelSemantic proximity Read ↗

Docetaxel induces cell death through mitotic catastrophe in human breast cancer cellsSemantic proximity Read ↗

Molecular mechanisms of docetaxel resistance in prostate cancerSemantic proximity Read ↗

Telling Cells How to Die: Docetaxel Therapy in Cancer Cell LinesSemantic proximity Read ↗

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategiesSemantic proximity Read ↗

Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer.Semantic proximity Read ↗

Alterations in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogenic resistant tumor cellsSemantic proximity Read ↗

Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistanceSemantic proximity Read ↗

Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulationSemantic proximity Read ↗

Polyploid giant cancer cells induced by Docetaxel exhibit a senescence phenotype with the expression of stem cell markers in ovarian cancer cells.Semantic proximity Read ↗

Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes.Semantic proximity Read ↗

Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.