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Article

Association of the FAM167A-BLK region with systemic sclerosis.

Arthritis and rheumatism - 1 Mar 2010

Ito Ikue, Kawaguchi Yasushi, Kawasaki Aya, Hasegawa Minoru, Ohashi Jun, Kawamoto Manabu, Fujimoto Manabu, Takehara Kazuhiko, Sato Shinichi, Hara Masako, Tsuchiya Naoyuki

Abstract excerpt

OBJECTIVE: An association of single-nucleotide polymorphisms (SNPs) in the FAM167A (previously referred to as C8orf13)-BLK region with systemic lupus erythematosus (SLE) has been demonstrated in Caucasians and in Asians. Recent studies have shown that many genes, including IRF5, STAT4, and PTPN22, are shared susceptibility genes in multiple autoimmune diseases. We undertook the current study to examine whether...

Read the complete abstract on PubMed

Topics

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Share to BLK gene
Share to PTPN22 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to STAT4 gene

Share to Genetic Predisposition to Disease

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

Share to Scleroderma, Systemic

Share to Systemic Sclerosis and Related Diseases

Source

Identifiers

PMID: 20131239
DOI: 10.1002/art.27303

Genes

BLK
PTPN22
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Association of the FAM167A-BLK region with systemic sclerosis.PMID 20131239Read ↗

Association of FAM167A-BLK rs2736340 Polymorphism with Susceptibility to Autoimmune Diseases: A Meta-Analysis.Semantic proximity Read ↗

Polymorphisms in the FAM167A-BLK, but not BANK1, are associated with primary Sjögren's syndrome in a Han Chinese population.Semantic proximity Read ↗

Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population.Semantic proximity Read ↗

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations.Semantic proximity Read ↗

C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis.Semantic proximity Read ↗

Possible single-nucleotide polymorphism loci associated with systemic sclerosis susceptibility: a genetic association study in a Chinese Han population.Semantic proximity Read ↗

Association studies of TNFSF4, TNFAIP3 and FAM167A-BLK polymorphisms with primary Sjogren's syndrome in Han Chinese.Semantic proximity Read ↗

Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.Semantic proximity Read ↗

Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.Semantic proximity Read ↗

The genetics of systemic sclerosis.Semantic proximity Read ↗

Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseases.Semantic proximity Read ↗

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