Article
Evaluation of SFRP1 as a candidate for human retinal dystrophies.
Molecular vision - 28 Jun 2004
Garcia-Hoyos Maria, Cantalapiedra Diego, Arroyo Carolina, Esteve Pilar, Rodríguez Josana, Riveiro Rosa, Trujillo Maria José, Ramos Carmen, Bovolenta Paola, Ayuso Carmen
Abstract excerpt
PURPOSE: Secreted Frizzled Related Proteins (SFRPs) are soluble molecules capable of modulating Wnt signalling. Different lines of evidence indicate that SFRP activity is related with the development and function of the retina photoreceptor cells as well as with their apoptotic degeneration associated with the onset of different cases of retinal dystrophy (RD). Because the genetic causes of many retinal...
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