Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population.

doi:10.1007/s12032-014-0168-4

Article

Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population.

Medical oncology (Northwood, London, England) - 1 Sept 2014

Sedaie Bonab Aida, Pouladi Nasser, Hosseinpourfeizi Mohammad Ali, Ravanbakhsh Gavgani Reyhaneh, Dehghan Roghayeh, Azarfam Parvin, Montazeri Vahid, Fakhrjou Ashraf

Abstract excerpt

The WRAP53 (WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage. Single nucleotide polymorphisms (SNPs) in WRAP53 have been associated with risk of cancer, which strengthens the role of WRAP53 in the pathogenesis of human malignancies. In fact, WRAP53 has been considered as a candidate cancer susceptibility gene. Accordingly, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population.

Abstract excerpt

Topics

Related research