Article
Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis.
Breast cancer research and treatment - 1 Jan 2007
Försti Asta, Jin Qianren, Altieri Andrea, Johansson Robert, Wagner Kerstin, Enquist Kerstin, Grzybowska Ewa, Pamula Jolanta, Pekala Wioletta, Hallmans Göran, Lenner Per, Hemminki Kari
Abstract excerpt
Angiogenesis is an important step in the development of cancer. Vascular endothelial growth factor is a major regulator of breast cancer angiogenesis, the effects of which are transmitted through the kinase domain receptor (KDR). Up-regulation of KDR by periostin (POSTN) induces angiogenesis. We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each...
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