Article
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Molecular cell - 8 Apr 2011
Kennedy Alyssa L, Morton Jennifer P, Manoharan Indrani, Nelson David M, Jamieson Nigel B, Pawlikowski Jeff S, McBryan Tony, Doyle Brendan, McKay Colin, Oien Karin A, Enders Greg H, Zhang Rugang, Sansom Owen J, Adams Peter D
Abstract excerpt
Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that activated PIK3CA/AKT is a weaker inducer of senescence than is activated RAS. Moreover, concurrent activation of RAS...
Topics
- Aged
- Animals
- Cell Line, Transformed
- Cell Proliferation
- Cellular Senescence
- Class I Phosphatidylinositol 3-Kinases
- Disease Models, Animal
- Enzyme Activation
- Female