Article
Akt-induced cellular senescence: implication for human disease.
Cell cycle (Georgetown, Tex.) - 1 Apr 2004
Minamino Tohru, Miyauchi Hideyuki, Tateno Kaoru, Kunieda Takeshige, Komuro Issei
Abstract excerpt
Reduction-of-function mutations in components of the insulin/insulin-like growth factor-1/Akt pathway have been shown to extend the lifespan in organisms ranging from yeast to mice. It has also been reported that activation of Akt induces proliferation and survival of mammalian cells, thereby promoting tumorigenesis. We have recently shown that Akt activity increases with cellular senescence and that inhibition...
Topics
- Animals
- Arteriosclerosis
- Cell Division
- Cellular Senescence
- Diabetes Mellitus
- Endothelium
- Humans
- Mice
- Models, Biological
- Mutation
- Protein Serine-Threonine Kinases