Article
Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas.
International journal of cancer - 15 Jun 2007
De Angelis Paula M, Stokke Trond, Beigi Marzieh, Flatberg Gøril, Enger Marianne, Haug Kristiane, Aass Hans Christian D, Schjølberg Aasa, Andresen Per Arne, Ariansen Sarah, Bø Anne Signe, Mjåland Odd, Clausen Ole Petter
Abstract excerpt
The order of appearance of different genetic aberrations during the shift from diploidy/near-diploidy to aneuploidy in colorectal cancers is not yet clear. We studied genetic alterations in flow cytometrically-sorted DNA diploid and corresponding aneuploid epithelial cell populations from each of 20 colorectal tumors using comparative genomic hybridization, FISH, and PCR. Analysis of the 19 cases in which...
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