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Article

Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice.

PloS one - 1 Jan 2013

Hoshino Tatsuya, Suzuki Koichiro, Matsushima Takahide, Yamakawa Naoki, Suzuki Toshiharu, Mizushima Tohru

Abstract excerpt

Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Aβ is generated by the secretase-mediated proteolysis of β-amyloid precursor protein (APP), and cleared by enzyme-mediated degradation and phagocytosis. Transforming growth factor (TGF)-β1 stimulates this phagocytosis. We recently reported that the APP23 mouse model for AD showed fewer AD-related phenotypes when these...

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Identifiers

PMID: 24098472
DOI: 10.1371/journal.pone.0076306
PMCID: PMC3788141

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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