Article
The signal transducer and activator of transcription 5B gene polymorphism contributes to the cholesterol metabolism in Japanese children with growth hormone deficiency.
Clinical endocrinology - 1 May 2011
Makimura Mika, Ihara Kenji, Kojima-Ishii Kanako, Nozaki Takafumi, Ohkubo Kazuhiro, Kohno Hitoshi, Kishimoto Junji, Hara Toshiro
Abstract excerpt
BACKGROUND AND AIMS: GH plays a significant role in the lipid metabolism. In this study, we focused on the JAK2 - signal transducer and activator of the transcription 5 (STAT5) pathway, which transmit the signals from the GH receptor, and selected the STAT5A/B gene as a candidate for the regulation of lipid metabolism in GH deficiency (GHD). DESIGN AND PARTICIPANTS: The study population comprised 83 children with...
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