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Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation

13 May 2014

Abstract excerpt

GH exerts a diverse array of physiological actions that include prominent roles in growth and metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects by influencing gene expression profiles, and Igf1 is a key transcriptional target of GH signaling in liver and other tissues. This review examines the mechanisms of GH-mediated gene regulation that begin with signal...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 24825400
DOI: 10.1210/me.2014-1099

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