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Article

Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients.

British journal of clinical pharmacology - 1 Apr 2012

Chew Sin Chi, Sandanaraj Edwin, Singh Onkar, Chen Xiangai, Tan Eng Huat, Lim Wan Teck, Lee Edmund J D, Chowbay Balram

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: SLCO1B3 is an influx transporter located at the hepatocyte basolateral membrane and it is involved in the uptake of a broad range of drug substrates including docetaxel. The pharmacogenetics of SLCO1B3 is not well characterized and previous in vivo and in vitro studies reported conflicting results with regards to the functional effects of the limited number of SLCO1B3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21995462
DOI: 10.1111/j.1365-2125.2011.04123.x
PMCID: PMC3376437

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