Article
HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis.
PLoS medicine - 1 Mar 2011
Zeh Clement, Weidle Paul J, Nafisa Lillian, Lwamba Humphrey M, Okonji Jully, Anyango Emily, Bondo Philip, Masaba Rose, Fowler Mary Glenn, Nkengasong John N, Thigpen Michael C, Thomas Timothy
Abstract excerpt
BACKGROUND: Nevirapine and lamivudine given to mothers are transmitted to infants via breastfeeding in quantities sufficient to have biologic effects on the virus; this may lead to an increased risk of a breastfed infant's development of resistance to maternal antiretrovirals. The Kisumu Breastfeeding Study (KiBS), a single-arm open-label prevention of mother-to-child HIV transmission (PMTCT) trial, assessed the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.