Article
Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis.
Retrovirology - 14 Aug 2013
Permar Sallie R, Salazar Maria G, Gao Feng, Cai Fangping, Learn Gerald H, Kalilani Linda, Hahn Beatrice H, Shaw George M, Salazar-Gonzalez Jesus F
Abstract excerpt
BACKGROUND: Intrapartum administration of single-dose nevirapine (sdNVP) reduces perinatal HIV-1 transmission in resource-limiting settings by half. Yet this strategy has limited effect on subsequent breast milk transmission, making the case for new treatment approaches to extend maternal/infant antiretroviral prophylaxis through the period of lactation. Maternal and transmitted infant HIV-1 variants frequently...
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