Article
Selection and persistence of viral resistance in HIV-infected children after exposure to single-dose nevirapine.
Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2007
Martinson Neil A, Morris Lynn, Gray Glenda, Moodley Daya, Pillay Visva, Cohen Sarah, Dhlamini Puleng, Puren Adrian, Bhayroo Schene, Steyn Jan, McIntyre James A
Abstract excerpt
BACKGROUND: Single-dose nevirapine (sd-NVP) is the mainstay of prevention of mother-to-child transmission programs in developing countries. Exposure to sd-NVP selects for resistance mutations, however. We longitudinally assessed these mutations in HIV-1-infected infants from Soweto and Durban, South Africa. METHODS: We prospectively followed 465 infants who received sd-NVP after enrolling their mothers when...
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