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Article

Tpl2 kinase regulates inflammation but not tumorigenesis in mice.

Toxicology and applied pharmacology - 1 May 2021

Wu Kai Connie, Cain Gary, Corpuz Janice, Xu Daqi, Ljumanovic Nina, Zarrin Ali A

Abstract excerpt

Tumor progression locus 2 (Tpl2, gene name MAP3K8), a mitogen-activated protein kinase, is widely expressed in immune and non-immune cells to integrate tumor necrosis factor (TNF), toll-like receptors (TLRs), and interleukin-1 (IL1) receptor signaling to regulate inflammatory response. Given its central role in inflammatory response, Tpl2 is an attractive small molecule drug target. However, the role of Tpl2 as...

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Identifiers

PMID: 33722668
DOI: 10.1016/j.taap.2021.115494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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