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Article

Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype.

Journal of hepatology - 1 May 2011

Tybl Elisabeth, Shi Fu-Dong, Kessler Sonja M, Tierling Sascha, Walter Jörn, Bohle Rainer M, Wieland Stefan, Zhang Jianying, Tan Eng M, Kiemer Alexandra K

Abstract excerpt

BACKGROUND & AIMS: The insulin-like growth-factor 2 (IGF2) mRNA binding protein p62 is highly expressed in hepatocellular carcinoma tissue. Still, its potential role in liver disease is largely unknown. In this study, we investigated pathophysiological implications of p62 overexpression in mice....

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Source

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Identifiers

PMID: 21145819
DOI: 10.1016/j.jhep.2010.08.034
PMCID: PMC3079004

Genes

IGF2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21145819-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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