Article
Heterozygous loss-of-function mutation in Odd-skipped related 1 (Osr1) is associated with vesicoureteric reflux, duplex systems, and hydronephrosis.
American journal of physiology. Renal physiology - 1 Nov 2017
Fillion Marie-Lyne, El Andalousi Jasmine, Tokhmafshan Fatima, Murugapoopathy Vasikar, Watt Christine L, Murawski Inga J, Capolicchio John-Paul, El-Sherbiny Mohamed, Jednak Roman, Gupta Indra R
Abstract excerpt
Odd-skipped related 1 (Osr1) is a transcriptional repressor that plays critical roles in maintaining the mesenchymal stem cell population within the developing kidney. Here, we report that newborn pups with a heterozygous null mutation in Osr1 exhibit a 21% incidence of vesicoureteric reflux and have hydronephrosis and urinary tract duplications. Newborn pups have a short intravesical ureter, resulting in a less...
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