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Article

Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product.

Neoplasia (New York, N.Y.) - 1 Aug 2014

Byrne Michael, Bennett Richard L, Cheng Xiaodong, May W Stratford

Abstract excerpt

The Nup98-HoxD13 (NHD13) fusion gene was identified in a patient with therapy-related myelodysplastic syndrome (MDS). When transgenically expressed in hematopoietic cells, mice faithfully recapitulate human disease with serial progression from peripheral blood (PB) cytopenias and increased bone marrow (BM) blasts to acute leukemia. It is well accepted that genomic instability in dysplastic hematopoietic...

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Identifiers

PMID: 25220590
DOI: 10.1016/j.neo.2014.07.004
PMCID: PMC4234872

Genes

NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product.PMID 25220590Read ↗

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