Article
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Oncogene - 9 May 2002
Fedele Monica, Battista Sabrina, Kenyon Lawrence, Baldassarre Gustavo, Fidanza Vincenzo, Klein-Szanto Andres J P, Parlow A F, Visone Rosa, Pierantoni Giovanna M, Outwater Eric, Santoro Massimo, Croce Carlo M, Fusco Alfredo
Abstract excerpt
Overexpression of the HMGA2 gene is a common feature of neoplastic cells both in experimental and human models. Intragenic and extragenic HMGA2 rearrangements responsible for HMGA2 gene overexpression have been frequently detected in human benign tumours of mesenchymal origin. To better understand the role of HMGA2 overexpression in human tumorigenesis, we have generated transgenic mice carrying the HMGA2 gene...
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