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Deregulated expression of <i>HMGA2</i> is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria

24 Oct 2011

Abstract excerpt

Patients with paroxysmal nocturnal haemoglobinuria (PNH) have expanded clonal cells bearing a somatic mutation in the PIGA gene. Our previous study on two PNH patients with chromosome 12 rearrangements demonstrated the involvement of HMGA2 expression in clonal expansion. The present study investigated HMGA2 expression in PNH patients without chromosomal abnormalities. The expression of short HMGA2 with latent...

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PMID: 22017592
DOI: 10.1111/j.1365-2141.2011.08914.x

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