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Article

Interferon-gamma receptor-1 gene promoter polymorphisms and susceptibility to leprosy in children of a single family.

The American journal of tropical medicine and hygiene - 1 Apr 2011

Velayati Ali A, Farnia Parissa, Khalizadeh Soheila, Farahbod Amir M, Hasanzadh Maryam, Sheikolslam Maryam F

Abstract excerpt

The autosomal recessive disorder, because of a single mutation in interferon-γ receptor-1(IFNGR1) at position -56, was found to be associated with susceptibility to leprosy in children of the same family. The existence of such heterozygous carriers might explain the crucial role of IFNGR1 in the host defense against intracellular pathogens such as Mycobacterium leprae. The single nucleotide polymorphisms (SNPs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21460021
DOI: 10.4269/ajtmh.2011.10-0515
PMCID: PMC3062460

Genes

IFNGR1
TNF
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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