Article
Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility.
Genes and immunity - 1 Mar 2009
Pereira A C, Brito-de-Souza V N, Cardoso C C, Dias-Baptista I M F, Parelli F P C, Venturini J, Villani-Moreno F R, Pacheco A G, Moraes M O
Abstract excerpt
Leprosy is a complex infectious disease influenced by genetic and environmental factors. The genetic contributing factors are considered heterogeneous and several genes have been consistently associated with susceptibility like PARK2, tumor necrosis factor (TNF), lymphotoxin-alpha (LTA) and vitamin-D receptor (VDR). Here, we combined a case-control study (374 patients and 380 controls), with meta-analysis (5...
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