Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype (Review).

doi:10.3892/ijmm.1.2.415

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Article

Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype (Review).

International journal of molecular medicine - 1 Feb 1998

Lamhamedi S, Jouanguy E, Altare F, Roesler J, Casanova J L

Abstract excerpt

Interferon-gamma receptor ligand binding chain (IFNgammaR1) deficiency is an autosomal recessive inherited immune disorder. Mutations in the IFNgR1 gene are associated with severe infections due to mycobacteria. However, several aspects of the phenotype of IFNgammaR1-deficient children have recen...

Topics

Environment
Genetic Heterogeneity
Genotype
Phenotype
Receptors, Interferon
Interferon gamma Receptor

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