Article
Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians.
The Canadian journal of cardiology - 1 Dec 2014
Chami Nathalie, Tadros Rafik, Lemarbre François, Lo Ken Sin, Beaudoin Mélissa, Robb Laura, Labuda Damian, Tardif Jean-Claude, Racine Normand, Talajic Mario, Lettre Guillaume
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of heart failure that may require heart transplantation. Approximately one third of DCM cases are familial. Next-generation DNA sequencing of large panels of candidate genes (ie, targeted sequencing) or of the whole exome can rapidly and economically identify pathogenic mutations in familial DCM. METHODS: We recruited 64 individuals from 26 DCM families...
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