Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes.

doi:10.1016/j.carpath.2024.107675

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Article

Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Bottillo Irene, Giordano Carla, Ciccone Maria Pia, Pignataro Maria Gemma, Albi Fiammetta, Parisi Gabriella, Formicola Daniela, Grotta Simona, Ranocchi Federico, Giuli Maria Valeria, Checquolo Saula, Masuelli Laura, Re Federica, Majore Silvia, d'Amati Giulia, Grammatico Paola

Abstract excerpt

Dilated cardiomyopathy (DCM) is defined as left ventricular enlargement accompanied by systolic dysfunction not explained by abnormal loading conditions or coronary heart disease. The DCM clinical spectrum is broad, ranging from subclinical to severe presentation with progression to end stage heart failure. To date, different genetic loci have been found to have moderate/definitive evidence for causality in DCM...

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PMID: 39059779
DOI: 10.1016/j.carpath.2024.107675

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