Article
The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions.
PLoS pathogens - 1 Aug 2020
Dallmann-Sauer Monica, Fava Vinicius M, Gzara Chaïma, Orlova Marianna, Van Thuc Nguyen, Thai Vu Hong, Alcaïs Alexandre, Abel Laurent, Cobat Aurélie, Schurr Erwin
Abstract excerpt
Leprosy is a chronic disease caused by Mycobacterium leprae. Worldwide, more than 200,000 new patients are affected by leprosy annually, making it the second most common mycobacterial disease after tuberculosis. The MHC/HLA region has been consistently identified as carrying major leprosy susceptibility variants in different populations at times with inconsistent results. To establish the unambiguous molecular...
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