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Article

Deep resequencing identifies candidate functional genes in leprosy GWAS loci.

PLoS neglected tropical diseases - 1 Dec 2021

Fava Vinicius M, Dallmann-Sauer Monica, Orlova Marianna, Correa-Macedo Wilian, Van Thuc Nguyen, Thai Vu Hong, Alcaïs Alexandre, Abel Laurent, Cobat Aurélie, Schurr Erwin

Abstract excerpt

Leprosy is the second most prevalent mycobacterial disease globally. Despite the existence of an effective therapy, leprosy incidence has consistently remained above 200,000 cases per year since 2010. Numerous host genetic factors have been identified for leprosy that contribute to the persistently high case numbers. In the past decade, genetic epidemiology approaches, including genome-wide association studies...

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PMID: 34879060
DOI: 10.1371/journal.pntd.0010029
PMCID: PMC8687567

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