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Article

Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy.

Nature genetics - 1 Apr 2007

Alcaïs Alexandre, Alter Andrea, Antoni Guillemette, Orlova Marianna, Nguyen Van Thuc, Singh Meenakshi, Vanderborght Patrícia R, Katoch Kiran, Mira Marcelo T, Vu Hong Thai, Ngyuen Thu Huong, Nguyen Ngoc Ba, Moraes Milton, Mehra Narinder, Schurr Erwin, Abel Laurent

Abstract excerpt

Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning. Here we report the linkage disequilibrium mapping of the second linkage peak of our previous genome-wide scan, located close to the HLA complex. In both a Vietnamese familial sample and an Indian case-control sample, the...

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Identifiers

PMID: 17353895
DOI: 10.1038/ng2000

Genes

LTA
PACRG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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