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Article

Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy.

Human genetics - 1 Jan 2013

Alter Andrea, Fava Vinicius Medeiros, Huong Nguyen Thu, Singh Meenakshi, Orlova Marianna, Van Thuc Nguyen, Katoch Kiran, Thai Vu Hong, Ba Nguyen Ngoc, Abel Laurent, Mehra Narinder, Alcaïs Alexandre, Schurr Erwin

Abstract excerpt

One of the persistent challenges of genetic association studies is the replication of genetic marker-disease associations across ethnic groups. Here, we conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese leprosy families. A total of 56 associated SNPs localized to the overlapping promoter regions of...

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PMID: 23052943
DOI: 10.1007/s00439-012-1227-6

Genes

PACRG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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