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Article

Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008

Barr Christina S, Schwandt Melanie L, Lindell Stephen G, Higley J Dee, Maestripieri Dario, Goldman David, Suomi Stephen J, Heilig Markus

Abstract excerpt

In a variety of species, development of attachment to a caregiver is crucial for infant survival and partly mediated by the endogenous opioids. Functional mu-opioid receptor gene polymorphisms are present in humans (OPRM1 A118G) and rhesus macaques (OPRM1 C77G). We hypothesized that rhesus infants carrying a gain-of-function OPRM1 77G allele would experience increased reward during maternal contact and would,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18378897
DOI: 10.1073/pnas.0710225105
PMCID: PMC2278187

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.PMID 18378897Read ↗

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Variation in the μ-opioid receptor gene (OPRM1) and experiences of felt security in response to a romantic partner's quarrelsome behavior.Semantic proximity Read ↗

Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients.Semantic proximity Read ↗

OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.Semantic proximity Read ↗

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