Article
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques.
Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2004
Barr Christina S, Newman Timothy K, Schwandt Melanie, Shannon Courtney, Dvoskin Rachel L, Lindell Stephen G, Taubman Julie, Thompson Bill, Champoux Maribeth, Lesch Klaus Peter, Goldman David, Suomi Stephen J, Higley J Dee
Abstract excerpt
A polymorphism in the human serotonin transporter gene promoter (5-HTTLPR) is associated with anxiety and increased risk for developing depression in the face of adversity. Here, we report that among infant rhesus macaques, an orthologous polymorphism (rh5-HTTLPR) interacts with adversity in the form of peer rearing to influence adrenocorticotropic hormone (ACTH) response to stress and, further, that this...
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