Genetic risk factors for pediatric-onset multiple sclerosis.

doi:10.1177/1352458517733551

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Article

Genetic risk factors for pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2018

Gianfrancesco Milena A, Stridh Pernilla, Shao Xiaorong, Rhead Brooke, Graves Jennifer S, Chitnis Tanuja, Waldman Amy, Lotze Timothy, Schreiner Teri, Belman Anita, Greenberg Benjamin, Weinstock-Guttman Bianca, Aaen Gregory, Tillema Jan M, Hart Janace, Caillier Stacy, Ness Jayne, Harris Yolanda, Rubin Jennifer, Candee Meghan, Krupp Lauren, Gorman Mark, Benson Leslie, Rodriguez Moses, Mar Soe, Kahn Ilana, Rose John, Roalstad Shelly, Casper T Charles, Shen Ling, Quach Hong, Quach Diana, Hillert Jan, Hedstrom Anna, Olsson Tomas, Kockum Ingrid, Alfredsson Lars, Schaefer Catherine, Barcellos Lisa F, Waubant Emmanuelle

Abstract excerpt

BACKGROUND: Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE: We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS: Cases with onset <18 years (n = 569) and controls...

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PMID: 28980494
DOI: 10.1177/1352458517733551
PMCID: PMC5878964

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