Article
HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.
Neurology - 1 Mar 2011
Disanto G, Magalhaes S, Handel A E, Morrison K M, Sadovnick A D, Ebers G C, Banwell B, Bar-Or A
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) in the pediatric age group is being increasingly recognized. In adults, complex interactions between genetic and environmental factors contribute to risk and the major genetic component of MS susceptibility localizes to the major histocompatibility complex (human leukocyte antigen [HLA]). Whether HLA alleles predict MS in at-risk children presenting with acquired demyelinating...
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