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Article

The role of autolysis loop in determining the specificity of coagulation proteases.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Aug 2007

Yang L, Manithody C, Rezaie A R

Abstract excerpt

We recently demonstrated that the substitution of the autolysis loop (residues 143 to 154 in the chymotrypsin numbering system) of activated protein C (APC) with the corresponding loop of factor Xa (fXa) renders the APC mutant (APC/fX143-154) susceptible to inhibition by antithrombin (AT) in the presence of pentasaccharide. Our recent results further indicated, that in addition to an improvement in the reactivity...

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Share to Antithrombins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

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Source

Identifiers

PMID: 17665041
DOI: 10.1590/s0100-879x2006005000137

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of autolysis loop in determining the specificity of coagulation proteases.PMID 17665041Read ↗

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