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Article

Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays.

Biophysical chemistry - 1 May 2008

Qureshi Shabir H, Manithody Chandrashekhara, Bae Jong-Sup, Yang Likui, Rezaie Alireza R

Abstract excerpt

We previously demonstrated that the substitution of the autolysis loop (residues 143-154 in chymotrypsin numbering) of APC with the corresponding loop of trypsin (APC-Tryp 143-154) has no influence on the proteolytic activity of the protease toward fVa, however, this substitution increases the reactivity of APC with plasma inhibitors so that the mutant exhibits no anticoagulant activity in plasma. To further...

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Identifiers

PMID: 18329782
DOI: 10.1016/j.bpc.2008.02.012
PMCID: PMC2387052

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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