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Article

Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.

The Journal of biological chemistry - 5 Dec 2008

Sangwan Veena, Paliouras Grigorios N, Abella Jasmine V, Dubé Nadia, Monast Anie, Tremblay Michel L, Park Morag

Abstract excerpt

The non-receptor protein-tyrosine phosphatases (PTPs) 1B and T-cell phosphatase (TCPTP) have been implicated as negative regulators of multiple signaling pathways including receptor-tyrosine kinases. We have identified PTP1B and TCPTP as negative regulators of the hepatocyte growth factor receptor, the Met receptor-tyrosine kinase. In vivo, loss of PTP1B or TCPTP enhances hepatocyte growth factor-mediated...

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Identifiers

PMID: 18819921
DOI: 10.1074/jbc.M805916200
PMCID: PMC2662243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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