Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met.

doi:10.1042/bj3360235

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Article

Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met.

The Biochemical journal - 15 Nov 1998

Villa-Moruzzi E, Puntoni F, Bardelli A, Vigna E, De Rosa S, Comoglio P M

Abstract excerpt

We reported previously that a protein tyrosine phosphatase (PTP) activity is associated with the immunoprecipitated hepatocyte growth factor (HGF) receptor, also known as Met. The activity increased reversibly when Met was stimulated by HGF and decreased when Met was inactivated by PMA. To identi...

Topics

3T3 Cells
Animals
Cell Membrane
Chromatography, Affinity
Mice
Mutation
Phosphopeptides
Phosphorylation
Protein Binding
Protein Tyrosine Phosphatases
Proto-Oncogene Proteins c-met
Tyrosine

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