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Article

The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.

Journal of neurochemistry - 1 Sept 2009

Mulherkar Shalaka A, Sharma Jaiprakash, Jana Nihar Ranjan

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder caused mainly because of the loss of dopaminergic neurons in the substantia nigra. Protein inclusions called Lewy bodies are the most common pathological hallmark of PD and other synucleinopathies. Because the main component of these inclusions is alpha-synuclein, aggregation of this protein is thought to be a key pathogenic event in this disease. In...

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Identifiers

PMID: 19645749
DOI: 10.1111/j.1471-4159.2009.06293.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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