Article
Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection.
The Journal of infectious diseases - 1 Oct 2013
Metzner Karin J, Scherrer Alexandra U, Preiswerk Benjamin, Joos Beda, von Wyl Viktor, Leemann Christine, Rieder Philip, Braun Dominique, Grube Christina, Kuster Herbert, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Furrer Hansjakob, Battegay Manuel, Vernazza Pietro L, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Weber Rainer, Günthard Huldrych F
Abstract excerpt
BACKGROUND: Drug-resistant human immunodeficiency virus type 1 (HIV-1) minority variants (MVs) are present in some antiretroviral therapy (ART)-naive patients. They may result from de novo mutagenesis or transmission. To date, the latter has not been proven. METHODS: MVs were quantified by allele-specific polymerase chain reaction in 204 acute or recent seroconverters from the Zurich Primary HIV Infection study...
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