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Article

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse.

Human molecular genetics - 15 Sept 2003

Itier Jean-Michel, Ibanez Pablo, Mena Maria Angeles, Abbas Nacer, Cohen-Salmon Charles, Bohme Georg Andrees, Laville Michel, Pratt Jeremy, Corti Olga, Pradier Laurent, Ret Gwenaelle, Joubert Chantal, Periquet Magali, Araujo Francisco, Negroni Julia, Casarejos Maria Jose, Canals Santiago, Solano Rosa, Serrano Alba, Gallego Eva, Sanchez Marina, Denefle Patrice, Benavides Jesus, Tremp Gunter, Rooney Thomas A, Brice Alexis, Garcia de Yebenes Justo

Abstract excerpt

Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive parkinsonism (EO-AR). Here we show that inactivation of the parkin gene in mice results in motor and cognitive deficits, inhibition of amphetamine-induced dopamine release and inhibition of glutamate neuro...

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Identifiers

PMID: 12915482
DOI: 10.1093/hmg/ddg239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12915482-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse.PMID 12915482Read ↗

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